Evidence supporting the use of: Isoquercitrin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoquercitrin is a flavonoid glycoside found in various fruits and medicinal plants. Its use for osteoporosis is grounded in emerging scientific research, rather than tradition. Preclinical studies, primarily in vitro and in animal models, suggest that isoquercitrin may have bone-protective effects. These effects are thought to be mediated through the inhibition of osteoclastogenesis (the formation of bone-resorbing cells), reduction of oxidative stress, and modulation of inflammatory pathways. For example, a 2020 study in the journal Phytomedicine demonstrated that isoquercitrin could inhibit osteoclast differentiation and bone resorption in mouse models. Other studies have indicated that isoquercitrin may promote osteoblast (bone-forming cell) activity, thereby potentially supporting bone formation.

However, there are currently no high-quality clinical trials in humans that demonstrate efficacy for osteoporosis prevention or treatment. The available evidence is preliminary and does not yet justify widespread clinical use. Isoquercitrin is sometimes included in dietary supplements marketed for bone health, but this is based primarily on laboratory data rather than robust clinical evidence. Thus, while the scientific rationale exists, the overall evidence supporting isoquercitrin for osteoporosis is weak (rated 2/5), and more research—especially in humans—is necessary to establish its role in osteoporosis management.

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Products containing isoquercitrin

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