Evidence supporting the use of: Kaempferol
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Kaempferol is a natural flavonoid found in many fruits, vegetables, and medicinal plants. Its use for osteoporosis is supported by preclinical scientific studies, but not yet by robust clinical trials in humans. Laboratory and animal studies have shown that kaempferol can promote osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation. For example, research published in journals such as “Phytomedicine” and “Bone” indicates that kaempferol may enhance bone mineral density and reduce bone loss in animal models of osteoporosis, possibly through its antioxidant and anti-inflammatory properties, as well as modulation of signaling pathways like Wnt/β-catenin and RANKL/OPG. However, there are currently no large, high-quality randomized clinical trials demonstrating kaempferol’s efficacy or safety for osteoporosis treatment or prevention in humans. As such, while the preclinical data are promising and suggest kaempferol could be beneficial in supporting bone health, the evidence is considered preliminary. The scientific community regards kaempferol as a potential supportive agent for osteoporosis, but further human studies are needed to validate its therapeutic use and determine effective dosages. At present, its use is not established by medical guidelines, and it should not replace conventional osteoporosis treatments.

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Products containing Kaempferol

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