Evidence supporting the use of: Leucine
For the health condition: Osteoporosis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Leucine, an essential branched-chain amino acid, has garnered some scientific interest regarding its potential role in supporting bone health and treating osteoporosis. Osteoporosis is characterized by decreased bone mass and increased fracture risk, often due to an imbalance between bone formation and resorption. Some experimental and observational studies suggest that leucine may stimulate muscle protein synthesis and, indirectly, improve bone health by supporting muscle mass and strength, which are critical for skeletal integrity and fall prevention. Additionally, preclinical research has indicated that leucine supplementation can influence osteoblast (bone-forming cell) activity and may modulate bone metabolism through the mTOR signaling pathway. However, direct clinical evidence in humans specifically linking leucine supplementation to improved bone mineral density or reduced fracture risk in osteoporosis patients is limited and inconsistent. Most studies to date have been conducted in animal models or as part of multi-nutrient supplementation, making it difficult to isolate the effects of leucine alone. Consequently, while there is a plausible biological rationale and some preliminary data, the overall quality and quantity of clinical evidence supporting leucine’s use specifically for osteoporosis is low. Current guidelines do not recommend leucine supplementation as a standard therapy for osteoporosis, and further large-scale human trials are needed to establish its efficacy and safety for this indication.

More about Leucine
More about Osteoporosis

Products containing Leucine

We currently have no products on Vitabase that contain this ingredient.