Relationship: Osteoporosis and manganese

Evidence supporting the use of: Manganese
For the health condition: Osteoporosis

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Synopsis
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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Manganese is an essential trace mineral involved in bone formation, metabolism, and overall skeletal health. Its role in bone health is primarily due to its function as a cofactor for enzymes involved in the synthesis of proteoglycans, which are important components of bone matrix. Several observational and animal studies have shown that manganese deficiency can lead to impaired bone formation and decreased bone mineral density. Additionally, manganese is a component of the antioxidant enzyme superoxide dismutase (MnSOD), which may play a protective role in bone cells by reducing oxidative stress, a factor implicated in osteoporosis. However, there is limited direct clinical evidence that manganese supplementation alone can prevent or treat osteoporosis in humans. Most studies and clinical trials on osteoporosis focus on calcium, vitamin D, and sometimes magnesium, but manganese is rarely studied as a primary intervention. Some research has evaluated multinutrient supplements containing manganese, finding modest benefits for bone markers, but it is difficult to isolate manganese’s specific effect. Overall, while there is clear biological plausibility and a scientific rationale for manganese’s role in bone health, and deficiency should be avoided, there is insufficient high-quality clinical evidence to strongly support manganese supplementation as a treatment for osteoporosis. Thus, its use is scientifically plausible but not robustly supported by clinical trials, leading to a moderate evidence rating.

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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Isoflavones
Milk Protein
Soy Protein

Other health conditions supported by manganese

Diabetes
Osteoporosis
Wounds and Sores

Products containing manganese

Health Concerns

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Evidence supporting the use of: Manganese
For the health condition: Osteoporosis

Table of Contents

Synopsis

Other ingredients used for Osteoporosis

Other health conditions supported by manganese

Products containing manganese

Health Concerns

Brands

Evidence supporting the use of: ManganeseFor the health condition: Osteoporosis

Table of Contents

Synopsis

Other ingredients used for Osteoporosis

Other health conditions supported by manganese

Products containing manganese

Evidence supporting the use of: Manganese
For the health condition: Osteoporosis