Evidence supporting the use of: Marine oil (unspecified)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Marine oil, such as fish oil rich in omega-3 fatty acids (EPA and DHA), has been investigated for its potential effects on bone health, including osteoporosis. The scientific rationale is based on the anti-inflammatory properties of omega-3s, which may help counteract bone loss driven by chronic inflammation. Some observational and preclinical studies suggest that higher intake of marine-derived omega-3 fatty acids may be associated with greater bone mineral density (BMD) or reduced risk of osteoporosis, particularly in older adults. Animal studies have demonstrated that omega-3 supplementation can favorably modulate bone turnover markers and improve bone strength. However, randomized controlled trials in humans have produced mixed results. Some trials report modest improvements in BMD or bone turnover markers, while others find no significant benefit over placebo. The current consensus in scientific literature is that while there is a plausible biological mechanism and some supportive data, the overall evidence is limited and not robust enough to recommend marine oil as a primary or sole intervention for osteoporosis. Most guidelines continue to emphasize calcium, vitamin D, and approved osteoporosis medications over marine oil supplements. Thus, while fish oil is sometimes used adjunctively, its role remains supplementary and not clearly established.

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