Evidence supporting the use of: Naringenin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Naringenin, a flavonoid predominantly found in citrus fruits, has garnered scientific interest for its potential role in supporting bone health and treating osteoporosis. Preclinical studies—mainly in vitro and animal models—have demonstrated that naringenin may exert positive effects on bone metabolism. Mechanistically, naringenin appears to promote osteoblast (bone-forming cell) differentiation and activity while inhibiting osteoclast (bone-resorbing cell) formation, potentially through the modulation of signaling pathways such as Wnt/β-catenin and RANKL/OPG. Additionally, its antioxidant and anti-inflammatory properties may contribute to the preservation of bone mass by mitigating oxidative stress and inflammatory cytokines, which are implicated in bone loss.

Despite these promising findings, clinical evidence in humans remains sparse. There are no large-scale, high-quality randomized controlled trials directly evaluating naringenin supplementation for osteoporosis treatment or prevention in humans. Most available data are limited to animal models (e.g., ovariectomized rats as a model of postmenopausal osteoporosis) and cell culture studies. As such, while the scientific rationale exists and preliminary evidence is supportive, the overall strength of evidence remains low (rated 2/5), and more human research is needed before naringenin can be confidently recommended for osteoporosis management.

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Products containing Naringenin

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