Evidence supporting the use of: Paeoniflorin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Paeoniflorin, a principal bioactive compound extracted from the root of Paeonia lactiflora (commonly known as peony), has been studied in recent years for its potential effects on osteoporosis. Preclinical studies, mainly in animal models and cellular systems, have demonstrated that paeoniflorin can inhibit osteoclast differentiation and bone resorption, as well as promote osteoblast activity and bone formation. The proposed mechanisms involve the regulation of RANKL/OPG signaling pathways, inhibition of inflammation, and antioxidative effects, all of which can contribute to improved bone metabolism and prevention of bone loss.

However, the evidence supporting paeoniflorin’s use in osteoporosis is currently limited to laboratory and animal studies. There are no well-designed clinical trials in humans that directly assess its efficacy or safety for osteoporosis prevention or treatment. While these preclinical findings are promising, they are not sufficient to establish paeoniflorin as an effective treatment for osteoporosis in clinical practice. More research, including controlled human studies, is required to confirm its therapeutic potential and to determine appropriate dosing and safety profiles.

In summary, while paeoniflorin is not a traditional remedy specifically for osteoporosis, there is growing scientific interest and preliminary evidence suggesting potential benefits. Based on current data, the evidence level for its use in osteoporosis is rated at 2 out of 5.

More about paeoniflorin
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc

Products containing paeoniflorin

We currently have no products on Vitabase that contain this ingredient.