Evidence supporting the use of: Parathyroid
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Parathyroid hormone (PTH), specifically as recombinant human parathyroid hormone (teriparatide), is scientifically validated and FDA-approved for the treatment of osteoporosis in certain populations. Teriparatide is a synthetic form of the first 34 amino acids of human PTH (PTH 1-34), which retains the biological activity of the full-length hormone. The scientific rationale for its use comes from its anabolic effects on bone: intermittent administration of PTH stimulates osteoblast activity more than osteoclast activity, leading to increased bone formation and improved bone architecture.

Multiple large, randomized, placebo-controlled trials have demonstrated that teriparatide significantly increases bone mineral density (BMD) at the spine and hip and reduces the risk of vertebral and non-vertebral fractures in postmenopausal women and men at high risk of fracture. For example, the pivotal Fracture Prevention Trial (published in NEJM, 2001) showed a 65% reduction in new vertebral fractures and a 53% reduction in nonvertebral fractures compared to placebo. Other studies have supported these findings and established teriparatide as an important therapeutic option, particularly in severe or glucocorticoid-induced osteoporosis.

Teriparatide is used for a limited duration (typically up to 2 years) due to concerns about potential risks, such as osteosarcoma observed in animal studies, though this has not been substantiated in humans. Overall, its use is based on robust, high-quality scientific evidence, making it a gold-standard anabolic treatment for osteoporosis.

More about Parathyroid
More about Osteoporosis

Other health conditions supported by Parathyroid

Calcium Deficiency
Osteoporosis

Products containing Parathyroid

We currently have no products on Vitabase that contain this ingredient.