Evidence supporting the use of: Polymethoxylated flavones
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polymethoxylated flavones (PMFs) are a group of flavonoids primarily found in citrus peels, such as tangeretin and nobiletin. There is emerging scientific evidence to suggest a potential benefit of PMFs in supporting bone health and possibly addressing osteoporosis, but the data are still preliminary. Several in vitro studies have demonstrated that PMFs can inhibit osteoclast differentiation and activity, which are processes involved in bone resorption. Additionally, some animal studies have indicated that PMFs may promote bone formation and increase bone mineral density by modulating signaling pathways such as RANKL/OPG and the Wnt/β-catenin pathway. However, direct clinical evidence in humans is lacking. Most of the current knowledge is based on basic research and animal models. A few studies, such as those published in journals like the Journal of Agricultural and Food Chemistry and Phytotherapy Research, have shown promising results in animal models of osteoporosis, but these findings have not yet been robustly confirmed in human trials. In summary, while there is a scientific rationale and early-stage evidence supporting the potential use of PMFs for osteoporosis, more research—especially well-controlled human clinical trials—is required to substantiate their effectiveness and safety for this purpose. Therefore, the evidence strength is rated as 2 out of 5.

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