Evidence supporting the use of: Polymethoxylated flavones
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polymethoxylated flavones (PMFs) are a group of flavonoids primarily found in citrus peels, such as tangeretin and nobiletin. There is emerging scientific evidence to suggest a potential benefit of PMFs in supporting bone health and possibly addressing osteoporosis, but the data are still preliminary. Several in vitro studies have demonstrated that PMFs can inhibit osteoclast differentiation and activity, which are processes involved in bone resorption. Additionally, some animal studies have indicated that PMFs may promote bone formation and increase bone mineral density by modulating signaling pathways such as RANKL/OPG and the Wnt/β-catenin pathway. However, direct clinical evidence in humans is lacking. Most of the current knowledge is based on basic research and animal models. A few studies, such as those published in journals like the Journal of Agricultural and Food Chemistry and Phytotherapy Research, have shown promising results in animal models of osteoporosis, but these findings have not yet been robustly confirmed in human trials. In summary, while there is a scientific rationale and early-stage evidence supporting the potential use of PMFs for osteoporosis, more research—especially well-controlled human clinical trials—is required to substantiate their effectiveness and safety for this purpose. Therefore, the evidence strength is rated as 2 out of 5.

More about polymethoxylated flavones
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
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Products containing polymethoxylated flavones

We currently have no products on Vitabase that contain this ingredient.