Evidence supporting the use of: Potassium citrate malate
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Potassium Citrate Malate and Osteoporosis: Evidence Synopsis

Potassium citrate malate has been investigated for its potential benefits in supporting bone health and the treatment or prevention of osteoporosis. The scientific rationale is based on the role of dietary acid-base balance in bone metabolism. Diets high in acid-producing foods (such as animal proteins and grains) may contribute to increased calcium loss from bones to buffer the acid load, potentially accelerating bone loss. Potassium salts of organic acids, such as potassium citrate and malate, are considered alkalinizing agents that can help neutralize dietary acid load.

Several clinical studies have demonstrated that supplementation with potassium citrate or potassium citrate malate can reduce urinary calcium excretion and markers of bone resorption, and may have a positive effect on bone mineral density (BMD) in postmenopausal women and older adults. For example, a 2009 randomized controlled trial by Jehle et al. (J Clin Endocrinol Metab) found that potassium citrate supplementation improved BMD in elderly men and women. Additional meta-analyses and reviews (e.g., Frassetto et al., 2011) suggest a modest but significant benefit of alkali salts in reducing bone turnover and improving calcium balance.

However, while the mechanism and early clinical results are promising, evidence is not yet robust enough for widespread clinical endorsement, as many studies are small or of short duration, and long-term fracture risk reduction has not been conclusively demonstrated. Therefore, potassium citrate malate is supported by moderate scientific evidence (rating: 3/5) for osteoporosis, primarily for its effects on bone metabolism markers rather than established clinical outcomes.

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Other health conditions supported by Potassium citrate malate

Calcium Deficiency
Calcium Deposits
Gout
Hypertension
Kidney Stones
Osteoporosis
Uric Acid Retention

Products containing Potassium citrate malate

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