Evidence supporting the use of: Proanthocyanidin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proanthocyanidins are a class of polyphenolic compounds found abundantly in foods such as grapes, berries, cocoa, and pine bark. Their use in supporting or treating osteoporosis is based on emerging scientific research, primarily conducted in cell and animal models, with a limited number of human studies. Preclinical studies suggest that proanthocyanidins may exert beneficial effects on bone health by promoting osteoblast (bone-forming cell) activity and inhibiting osteoclast (bone-resorbing cell) differentiation, largely due to their antioxidant and anti-inflammatory properties. For example, studies have shown that proanthocyanidins can reduce oxidative stress, which is implicated in bone loss and osteoporosis. In some rodent models, supplementation with proanthocyanidins has led to improvements in bone mineral density and bone microarchitecture.

However, clinical data in humans are sparse. A few small-scale studies have indicated potential benefits, but these results are preliminary and not yet conclusive. No major clinical guidelines currently recommend proanthocyanidins for osteoporosis treatment, and more robust, large-scale human trials are needed to establish efficacy and safety. Therefore, while there is a scientific rationale and some preclinical support for the use of proanthocyanidins in osteoporosis, the current level of evidence is low, justifying a cautious and investigational approach.

More about Proanthocyanidin
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Products containing Proanthocyanidin

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