Evidence supporting the use of: Proanthocyanidins
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proanthocyanidins, a class of polyphenolic compounds found in foods such as grapes, berries, and cocoa, have been investigated for their potential benefits in supporting bone health, including osteoporosis. Some laboratory and animal studies suggest that proanthocyanidins may exert positive effects on bone metabolism. Specifically, they have been shown to possess antioxidant and anti-inflammatory properties that could potentially inhibit bone resorption (the breakdown of bone tissue) and stimulate osteoblast (bone-forming cell) activity. For example, studies in ovariectomized rats—a common animal model for postmenopausal osteoporosis—have reported that supplementation with proanthocyanidins can reduce bone loss and improve bone microarchitecture. Additionally, in vitro studies indicate that proanthocyanidins may modulate signaling pathways involved in bone turnover. However, clinical evidence in humans is very limited. To date, there are few, if any, well-designed randomized controlled trials directly evaluating the effect of proanthocyanidin supplementation on bone mineral density or fracture risk in humans with osteoporosis. Most of the supportive data come from preclinical research, and these findings have not yet been robustly translated into clinical practice. Therefore, while there is a scientific rationale and some promising preclinical evidence, the overall strength of evidence is currently low (rated 2 out of 5), and proanthocyanidins should not be considered a proven treatment for osteoporosis at this time.

More about proanthocyanidins
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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc

Products containing proanthocyanidins

We currently have no products on Vitabase that contain this ingredient.