Evidence supporting the use of: Puerarin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Puerarin, an isoflavone derived from the root of Pueraria lobata (Kudzu), has been studied for its potential effects in supporting or treating osteoporosis, particularly in postmenopausal models. The scientific rationale centers on its phytoestrogenic activity, as it can bind to estrogen receptors and modulate bone metabolism, which is crucial since estrogen deficiency is a major factor in postmenopausal osteoporosis. Several in vitro and animal studies have reported that puerarin can stimulate osteoblast activity (bone formation) and inhibit osteoclast differentiation (bone resorption), leading to improved bone mineral density and microarchitecture in ovariectomized rat models. These effects have been linked to modulation of signaling pathways such as Wnt/β-catenin and inhibition of RANKL-mediated osteoclastogenesis.

However, clinical evidence in humans is limited. Most of the current data are preclinical, and while promising, do not yet provide strong support for widespread clinical use. There are very few, if any, well-designed randomized controlled trials in humans assessing puerarin's efficacy or safety for osteoporosis. As such, the evidence supporting its use is preliminary, giving it a rating of 2 out of 5. Ongoing and future clinical studies are needed to confirm whether these benefits translate to human populations.

More about Puerarin
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Fo-Ti
formononetin
Fish
Flavanones
Flavans
Flavanols
Flavones
Hyperoside
Isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral Blend
Marine Protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
Polysaccharides
Procyanidin
Proanthocyanidins
Polyunsaturated Fat
Paeoniflorin
Phytoestrogens
Polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll

Products containing Puerarin

We currently have no products on Vitabase that contain this ingredient.