Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rehmannia glutinosa is a traditional Chinese medicinal herb that has been used in formulas to support bone health and treat conditions associated with bone weakness, such as osteoporosis. The use of Rehmannia is rooted in traditional Chinese medicine (TCM), where it is considered to nourish the “kidney,” an organ system believed to govern bone strength. However, beyond traditional use, there is some emerging scientific evidence supporting its potential benefit for osteoporosis.

Preclinical studies (mainly in vitro and animal models) have indicated that extracts of Rehmannia, particularly its component catalpol, may promote osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) activity. These effects are thought to occur via modulation of pathways such as the RANKL/OPG system, which is central to bone remodeling. Some studies have also reported that Rehmannia can help mitigate bone loss in ovariectomized rats, an established animal model for postmenopausal osteoporosis.

However, robust human clinical data are lacking. Most evidence comes from laboratory and animal studies, and the translation to clinical efficacy and safety in humans remains unproven. Therefore, while there is a scientific rationale and preclinical support for the use of Rehmannia in osteoporosis, the overall quality and quantity of evidence is limited, justifying a modest evidence rating.

More about Rehmannia
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
8-Prenylnaringenin
Abalone
Acacetin
Alfalfa
algal oil
Algal protein
Algalin
Algas calcareas
alpha-ketoglutarate (AKG)
AMP-activated protein kinase (AMPK)
ampelopsin
animal protein
animal Tissue
anthocyanins
antler
apigenin
arctiin
ashwagandha
astragalin
astragaloside
astragalus
barrenwort
beta caryophyllene
biochanin
blueberry
bok choy
bone protein
boron
bovine
bovine protein
broccoli
calcium
calycosin
catechins
caterpillar mushroom
Chinese Ligustrum berry
Cissus quadrangularis
cistanche
cod liver oil
collagen
collard
conjugated linoleic acid (CLA)
curcumin
cyanidin
daidzein
DHEA
DHEA (dehydroepiandrosterone)
dioscorea
diosgenin
diosmetin
DPA (docosapentaenoic acid)
Drynaria
ecdysteroids
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epicatechin
equol (proprietary)
estrogen
Eucommia ulmoides
fern
fish
fish protein
flavanols
flavanones
flavans
flavones
fo-ti
formononetin
genistein
genistin
glycitin
goji berry
gooseberry
haliotis
hesperetin
hesperidin
horsetail
Hyperoside
icariin
ipriflavone
isoflavones
Kaempferol
kale
knotweed
Legume protein
Lentinula edodes mycelia
lignans
Lithothamnion
Lycium
maca
magnesium
manganese
Marine protein
Microcrystalline hydroxyapatite concentrate (MCHC)
Milk Protein
Mineral blend
Naringenin
Neoeriocitrin
olive
omega-3 fatty acids
paeoniflorin
Phaeophyceae
phosphorus
Phytoecdysteroid
Phytoestrogens
polymethoxylated flavones
polysaccharides
polyunsaturated fat
pomegranate
proanthocyanidins
procyanidin
prune
Puerarin
quercetin
red clover
Rehmannia
rehmannia glutinosa
resveratrol
royal jelly
rutin
seaweed
sesame
Shilajit
silica
silicon
Soy
soy isoflavones
Soy Protein
soybean
specialized pro-resolving mediators (SPMs)
Stilbenoid
strontium
tocotrienols
Ursolic Acid
Vegetable Protein
vitamin C
vitamin D
vitamin D3
vitamin K
Wakame
Whey protein
Xanthophyll
Zinc

Other health conditions supported by Rehmannia

Anemia
Diabetes
Fatigue
Hypertension
Kidney Stones
Memory and Brain Function
Menopause
Osteoporosis
Stress
Ulcers

Products containing Rehmannia

We currently have no products on Vitabase that contain this ingredient.