Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rehmannia glutinosa is a traditional Chinese medicinal herb commonly used in formulas to nourish the kidney and liver, concepts closely linked in Traditional Chinese Medicine (TCM) to bone health and osteoporosis. While its use is rooted in tradition, there is also emerging scientific evidence suggesting potential benefits for osteoporosis. Preclinical studies (primarily in animal models) indicate that extracts of Rehmannia glutinosa may exert protective effects on bone metabolism. For example, research has shown that catalpol, an active compound in Rehmannia, can promote osteoblast proliferation and differentiation, suppress osteoclast activity, and improve bone mineral density in ovariectomized rats—a common model for postmenopausal osteoporosis (J Ethnopharmacol, 2017; Phytomedicine, 2018). Additionally, some studies suggest anti-inflammatory and antioxidant actions that could further support bone health. However, robust clinical trials in humans are lacking, and the majority of scientific data comes from laboratory or animal studies. Thus, while there is a scientific rationale and promising preclinical evidence, the current level of clinical evidence is limited. Therefore, the use of Rehmannia glutinosa for osteoporosis can be described as having scientific support, but the strength of evidence remains low (rated 2/5), awaiting more rigorous human studies to confirm efficacy and safety.

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