Evidence supporting the use of: Resveratrol
For the health condition: Osteoporosis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, red wine, and certain berries, has been investigated for its potential role in supporting bone health and treating osteoporosis. Scientific interest in resveratrol arises from its antioxidant and anti-inflammatory properties, as well as its ability to modulate signaling pathways involved in bone metabolism. Preclinical studies in animal models and in vitro experiments have shown that resveratrol can stimulate osteoblast (bone-forming cell) activity and inhibit osteoclast (bone-resorbing cell) differentiation, potentially leading to increased bone formation and decreased bone resorption. These effects are thought to be mediated by the activation of SIRT1 (sirtuin 1) and the Wnt/β-catenin signaling pathway, both of which are involved in bone homeostasis.

However, clinical evidence in humans remains limited and inconclusive. Some small-scale clinical trials have suggested a modest benefit of resveratrol supplementation on bone mineral density or markers of bone turnover, particularly in postmenopausal women, but the results are not robust or widely replicated. Dosage, duration, and formulation differences further complicate interpretations. As such, while there is a scientific rationale and some preliminary evidence supporting resveratrol's use for osteoporosis, the overall quality and quantity of clinical data remain insufficient to strongly endorse its use as a primary or adjunct therapy for this condition.

More about resveratrol
More about Osteoporosis

Products containing resveratrol

Vitabase Active Woman's Multi
Thorne Advanced Nutrients Multivitamin
Designs For Health ArthroSoothe™
Designs For Health ArthroSoothe™ Supreme
Pure Encapsulations Balanced Immune
Designs For Health BioFizz® Immune
Designs For Health CellGuard-NR 60 Capsules
Designs For Health FemGuard+Balance™
Designs For Health Inflammatone™
Designs For Health Inflammatone™
Klean Athlete Klean Multivitamin ™
Thorne L-Arginine Plus Perfusia Plus
Pure Encapsulations Memory Pro
Pure Encapsulations Memory Pro
Pure Encapsulations Metabolic Xtra
Douglas Laboratories Methlyated Resveratrol Plus
Pure Encapsulations Mitochondria-ATP
Designs For Health Mitochondrial NRG™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Thorne PolyResveratrol-SR
Designs For Health Primal Multi™
Pure Encapsulations Renual
Pure Encapsulations ResCu-SR®
Thorne ResveraCel
Pure Encapsulations Resveratrol
Pure Encapsulations Resveratrol
Douglas Laboratories Resveratrol
Pure Encapsulations Resveratrol Extra
Pure Encapsulations Resveratrol Extra
Designs For Health Resveratrol Supreme
Integrative Therapeutics Resveratrol Ultra HP 175mg
Pure Encapsulations Resveratrol VESIsorb®
Pure Encapsulations RevitalAge™ Ultra
Designs For Health Ultimate Antiox Full Spectrum
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Pure Encapsulations Ultra Pure Pack
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Vitabase Women's Support