Evidence supporting the use of: Resveratrol analogue
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis

Resveratrol, a natural polyphenol found in grapes and red wine, and its analogues have been investigated for their potential role in supporting or treating osteoporosis. Preclinical studies, primarily in animal models and in vitro experiments, suggest that resveratrol and its analogues can positively influence bone metabolism. These effects are thought to be mediated through the activation of SIRT1 (a sirtuin protein), reduction of oxidative stress, inhibition of osteoclast differentiation (bone resorption), and promotion of osteoblast activity (bone formation).

Several animal studies have demonstrated that resveratrol supplementation may increase bone mineral density (BMD) and improve bone microarchitecture in models of osteoporosis, particularly in ovariectomized rodents that mimic postmenopausal osteoporosis. Additionally, some research has shown that resveratrol analogues may have enhanced bioavailability and similar or improved efficacy compared to resveratrol itself.

However, clinical evidence in humans is limited. A handful of small clinical trials have explored the effects of resveratrol supplementation on bone markers in postmenopausal women, with mixed results. Some report modest improvements in bone turnover markers, but robust data on fracture risk reduction or significant improvements in BMD are lacking. As such, while there is promising preclinical evidence and some early clinical observations, the overall level of scientific validation remains low, and further high-quality human studies are needed.

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