Evidence supporting the use of: Rhaponticin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rhaponticin is a natural stilbene glycoside found primarily in Rheum rhaponticum (rhubarb). Recent scientific studies, mostly in vitro and in animal models, suggest that rhaponticin may have potential benefits for bone health, particularly in the context of osteoporosis. The primary mechanism proposed is its phytoestrogenic activity, whereby rhaponticin can mimic some effects of estrogen, a hormone whose deficiency is a key factor in postmenopausal osteoporosis. Some preclinical studies have shown that rhaponticin can stimulate osteoblastic differentiation and inhibit osteoclastogenesis, thereby promoting bone formation and inhibiting bone resorption. For instance, a 2017 study in mice demonstrated that rhaponticin supplementation alleviated bone loss induced by estrogen deficiency, with improvements in bone mineral density and bone microarchitecture.

However, there is a lack of robust clinical evidence in humans. No large-scale, randomized controlled trials have been published to confirm its efficacy or safety in treating or preventing osteoporosis in humans. The available evidence is promising but preliminary, and further research—including human clinical trials—is needed before rhaponticin can be recommended as a standard therapy for osteoporosis. Thus, the evidence supporting the use of rhaponticin for osteoporosis is scientific in origin but currently limited, warranting a moderate-low evidence rating.

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