Evidence supporting the use of: Rutin
For the health condition: Osteoporosis

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rutin, a flavonoid glycoside found in various plants such as buckwheat, citrus fruits, and apples, has been investigated for its potential benefits in bone health, including osteoporosis. Preclinical studies, primarily in animal models and cell cultures, suggest that rutin may exert protective effects against osteoporosis through its antioxidant, anti-inflammatory, and anti-osteoclastogenic properties. Rutin appears to mitigate oxidative stress—a factor implicated in bone loss—by scavenging free radicals and upregulating antioxidant enzymes. Additionally, some studies indicate that rutin can inhibit the differentiation and activity of osteoclasts (cells responsible for bone resorption), while promoting osteoblast function (cells responsible for bone formation). For example, research in ovariectomized rats (a common model for postmenopausal osteoporosis) has demonstrated that rutin supplementation can prevent bone mineral density loss and improve bone microarchitecture.

However, despite promising laboratory and animal data, robust clinical trials in humans are lacking. There is insufficient evidence to recommend rutin as a primary or adjunctive therapy for osteoporosis in clinical practice. The current scientific support is limited to preclinical research, and its translation to human health outcomes remains uncertain. Therefore, while the use of rutin for osteoporosis is scientifically grounded in mechanistic studies, the overall evidence is weak (rated 2/5), and routine clinical use cannot be justified without further research.

More about rutin
More about Osteoporosis

Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Fo-Ti
formononetin
Fish
Flavanones
Flavans
Flavanols
Flavones
Hyperoside
Isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral Blend
Marine Protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
Polysaccharides
Procyanidin
Proanthocyanidins
Polyunsaturated Fat
Paeoniflorin
Phytoestrogens
Polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll