Evidence supporting the use of: Testolone
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Testolone (RAD140) is a selective androgen receptor modulator (SARM) investigated primarily for its potential to increase muscle mass and bone density. The scientific rationale for its use in supporting or treating osteoporosis stems from its anabolic effects on bone and muscle tissue, mimicking some of the beneficial actions of testosterone but with potentially fewer androgenic side effects. Preclinical studies, particularly in rodent models, have demonstrated that RAD140 can improve bone mineral density and strength, likely by stimulating osteoblastic (bone-forming) activity and inhibiting osteoclastic (bone-resorbing) activity. For example, a 2017 study in the journal ACS Medicinal Chemistry Letters reported that RAD140 increased bone mineral density and lean body mass in ovariectomized rats, a common model for postmenopausal osteoporosis.

However, it is important to note that, as of mid-2024, there is a lack of published, peer-reviewed human clinical trial data specifically evaluating Testolone for osteoporosis. Most evidence is limited to animal studies and early phase clinical trials focusing on muscle wasting disorders or cancer-related cachexia. While the mechanism of action and preclinical data indicate potential for osteoporosis treatment, more rigorous human studies are required to establish both efficacy and safety. Thus, while there is scientific validation at the preclinical level, the current evidence supporting Testolone's use for osteoporosis in humans remains moderate and preliminary.

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