Evidence supporting the use of: Testosterone precursor (unspecified)
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Testosterone precursors, such as dehydroepiandrosterone (DHEA) and androstenedione, have been investigated for their potential role in the treatment or support of osteoporosis, particularly in men or postmenopausal women with low endogenous testosterone levels. Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk, and testosterone is known to play a critical role in maintaining bone health by promoting bone formation and reducing bone resorption. Clinical studies have shown that testosterone replacement therapy in hypogonadal men can increase BMD and may reduce fracture risk; however, the evidence for testosterone precursors is less robust.

Some randomized controlled trials have demonstrated modest improvements in BMD with DHEA supplementation, especially in older women and men with low DHEA levels, but results are inconsistent and the effect size is generally smaller than that seen with direct testosterone or established osteoporosis treatments. The use of unspecified testosterone precursors is not standard of care, and their efficacy and safety profile remain uncertain. Major guidelines (e.g., Endocrine Society, National Osteoporosis Foundation) do not recommend testosterone precursors as primary or routine therapy for osteoporosis.

In summary, while there is a physiological rationale and moderate scientific evidence that testosterone and its precursors may have a beneficial effect on bone health, the evidence supporting the use of unspecified testosterone precursors in osteoporosis is limited and not definitive. Further large-scale, long-term studies are needed to clarify their role.

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