Relationship: Osteoporosis and vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D3 (cholecalciferol) is scientifically validated as an important component in the prevention and management of osteoporosis. Osteoporosis is characterized by decreased bone mass and increased fracture risk, often resulting from impaired bone remodeling. Vitamin D3 plays a central role in calcium and phosphorus homeostasis by promoting their absorption in the intestines, which is necessary for proper bone mineralization. Deficiency in vitamin D can lead to decreased calcium absorption, secondary hyperparathyroidism, bone loss, and increased fracture risk.

Multiple randomized controlled trials and meta-analyses have shown that vitamin D supplementation, particularly when combined with calcium, can reduce bone loss and lower the risk of fractures, especially in older adults and postmenopausal women. For example, a 2014 meta-analysis in Lancet Diabetes & Endocrinology found that combined vitamin D and calcium supplementation reduced fracture risk, though the effect of vitamin D alone is less pronounced if calcium intake is adequate. Guidelines from organizations such as the National Osteoporosis Foundation and the Endocrine Society recommend vitamin D supplementation for individuals at risk of osteoporosis or with documented deficiency.

However, while robust evidence supports vitamin D3's role in bone health and osteoporosis prevention, optimal dosing and the benefit of supplementation in vitamin D-sufficient individuals remain areas of active research. Overall, there is strong scientific support for using vitamin D3 to support bone health and help manage osteoporosis, particularly as part of a broader strategy including calcium intake and lifestyle measures.

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Other ingredients used for Osteoporosis

7-hydroxymatairesinol (HMR)
alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Isoflavones
Milk Protein
Soy Protein

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Evidence supporting the use of: Vitamin D3
For the health condition: Osteoporosis

Table of Contents

Synopsis

Other ingredients used for Osteoporosis

Other health conditions supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the health condition: Osteoporosis

Table of Contents

Synopsis

Other ingredients used for Osteoporosis

Other health conditions supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the health condition: Osteoporosis