Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin K, particularly in the forms of K1 (phylloquinone) and K2 (menaquinone), has been explored for its role in bone health and the prevention or treatment of osteoporosis. The biological rationale is that vitamin K is an essential cofactor for the carboxylation of osteocalcin, a protein crucial for bone mineralization. Some epidemiological studies have found associations between higher vitamin K intake and increased bone mineral density or reduced fracture risk, particularly in postmenopausal women. Additionally, randomized controlled trials (RCTs), mainly conducted in Japan using high-dose vitamin K2 (menaquinone-4), have shown modest benefits in reducing vertebral fractures, but results are inconsistent and often not replicated in Western populations or with vitamin K1 supplementation.

Systematic reviews and meta-analyses indicate that while vitamin K supplementation may improve biochemical markers of bone health, its impact on actual fracture rates or significant increases in bone mineral density is uncertain. Leading organizations, such as the National Osteoporosis Foundation and International Osteoporosis Foundation, do not currently recommend vitamin K supplementation for osteoporosis prevention or treatment outside of individuals with deficiency or those on long-term anticoagulant therapy (e.g., warfarin). Thus, while there is a scientific rationale and some supportive evidence, the overall quality and consistency of clinical evidence are limited, and routine use is not widely endorsed.

More about vitamin K
More about Osteoporosis

Other ingredients used for Osteoporosis

Other health conditions supported by vitamin K

Products containing vitamin K

Vitabase Active Woman's Multi
Designs For Health ADK-Evail™
Thorne Advanced Nutrients Multivitamin
Metagenics Axis Endo™ Mango
Thorne Basic Nutrients 2/Day Multivitamin
Thorne Basic Prenatal Multivitamin
Designs For Health BRF 45™
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations CAL+ with Ipriflavone
Pure Encapsulations Calcium K/D
Vitabase Calcium & Magnesium Citrates
Integrative Therapeutics Clinical Nutrients HP
Designs For Health D Evail™ 10K
Designs For Health D-Evail™ Supreme
Designs For Health DFH Complete Multi™
Designs For Health DFH Complete Multi™ with Copper
Designs For Health DFH Complete Multi™ with Copper & Iron
Designs For Health Emulsi-D3 Synergy™
Pure Encapsulations EmulsiSorb K2D3
Metagenics Fem Prenatal®
Douglas Laboratories K2-D3 with Astaxanthin
Vitabase Life's Essentials Plus
Designs For Health Liposomal D Supreme
Douglas Laboratories Liquid D and K
Designs For Health Metabolic Synergy™
Designs For Health Metabolic Synergy™
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Thorne Multi-Vitamin Elite NSF
Thorne Multi-Vitamin Elite NSF
Pure Encapsulations Nutrient 950® with Vitamin K
Integrative Therapeutics Nutrivitamin No-Iron
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Designs For Health Osteoben®
Designs For Health OsteoForce™
Designs For Health OsteoForce™
Designs For Health OsteoForce™ Supreme
Integrative Therapeutics Osteoprime Forte
Integrative Therapeutics Osteoprime Ultra
Integrative Therapeutics Physicians Elemental Diet Dextrose Free
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physician's Elemental Diet
Integrative Therapeutics Physicians Elemental Diet Kit
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Metagenics PlusOne® Daily Prenatal Packs
Douglas Laboratories Prenatal
Pure Encapsulations PreNatal Nutrients
Pure Encapsulations PreNatal Nutrients
Designs For Health Prenatal Pro™
Designs For Health Primal Multi™
Integrative Therapeutics ProThrivers Multivitamin
Pure Encapsulations PureGenomics® Multivitamin
Pure Encapsulations PureGenomics® UltraMultivitamin
Pure Encapsulations PureHeart® K2D
Pure Encapsulations PureLean® Protein
Pure Encapsulations PureResponse™ Multivitamin
Pure Encapsulations Synergy K
Pure Encapsulations Synergy K
Designs For Health Tri-K™
Designs For Health Twice Daily Essential Packets
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Designs For Health Twice Daily Multi™
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories ULTRA PREVENTIVE® III W/COPPER
Douglas Laboratories Ultra Preventive® X
Douglas Laboratories Ultra Protein Green
Thorne Vitamin D + K2
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Supreme
Designs For Health Vitamin D Synergy
Metagenics Vitamin D3 10,000 + K
Metagenics Vitamin D3 5000 + K
Thorne Vitamin K (formerly 3-K Complete)
Thorne Vitamin K2
Douglas Laboratories Vitamin K2
Integrative Therapeutics Vitamin K2+D3
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Thorne Women's Multi 50+
Pure Encapsulations Women's Nutrients
Pure Encapsulations Women's Nutrients
Designs For Health Women's Twice Daily Essential Packets