Evidence supporting the use of: Vitamin K mixed)
For the health condition: Osteoporosis
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin K, particularly in its forms K1 (phylloquinone) and K2 (menaquinone), has a scientifically investigated role in bone health and osteoporosis. Multiple observational studies and some clinical trials suggest that Vitamin K is involved in bone metabolism by acting as a cofactor for the enzyme γ-glutamyl carboxylase, which is necessary for the carboxylation of osteocalcin, a protein critical for bone mineralization. Epidemiological evidence indicates that low Vitamin K status is associated with increased fracture risk and low bone mineral density. Some randomized controlled trials, especially in Japan using high-dose Vitamin K2 (menaquinone-4), have shown reduced vertebral fractures and slowed bone loss in postmenopausal women. However, results are mixed, and studies in Western populations using lower doses have been less consistently positive. Meta-analyses generally support a modest benefit, particularly for Vitamin K2, but also emphasize the need for larger and longer-term trials. While Vitamin K supplementation is not a first-line or universally accepted treatment for osteoporosis, its use as an adjunct is supported by moderate scientific evidence, especially in populations with low dietary intake or increased risk of deficiency. Major guidelines do not currently recommend routine Vitamin K supplementation solely for osteoporosis prevention or treatment.
Other ingredients used for Osteoporosis
7-hydroxymatairesinol (HMR)Alfalfa
algal oil
alpha-ketoglutarate (AKG)
anthocyanins
ashwagandha
astragalus
beta caryophyllene
sesame
blueberry
boron
bovine
broccoli
calcium
catechins
caterpillar mushroom
cissus quadrangularis
collagen
collard
conjugated linoleic acid (CLA)
curcumin
DHEA (dehydroepiandrosterone)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
fish protein
genistein
genistin
glycitin
gooseberry
hesperetin
hesperidin
horsetail
ipriflavone
knotweed
kale
lentinula edodes mycelia
lignans
maca
magnesium
manganese
microcrystalline hydroxyapatite concentrate (MCHC)
olive
omega-3 fatty acids
phosphorus
pomegranate
prune
quercetin
rehmannia glutinosa
resveratrol
rutin
sardines
silicon
soybean
specialized pro-resolving mediators (SPMs)
strontium
tocotrienols
tomato
vitamin C
vitamin D
vitamin D3
vitamin K
seaweed
whey protein
zinc
red clover
haliotis
cistanche
dioscorea
fern
royal jelly
Equol (proprietary)
barrenwort
goji berry
AMP-activated protein kinase (AMPK)
soy isoflavones
8-Prenylnaringenin
Animal Tissue
Antler
Apigenin
Algas calcareas
Acacetin
Astragaloside
Ampelopsin
Algal protein
Algalin
Abalone
Arctiin
Astragalin
Animal protein
Bok Choy
Bovine Protein
biochanin
Bone Protein
Calycosin
Cod Liver Oil
Cyanidin
Chinese Ligustrum berry
DHEA
Daidzein
Diosgenin
Drynaria
Diosmetin
epicatechin
Ecdysteroids
Eicosapentaenoic Acid
Eucommia ulmoides
Estrogen
Fo-Ti
formononetin
Fish
Flavanones
Flavans
Flavanols
Flavones
Hyperoside
Isoflavones
icariin
Kaempferol
Lycium
Lithothamnion
Legume protein
Mineral Blend
Marine Protein
Milk Protein
Naringenin
Neoeriocitrin
Puerarin
Phytoecdysteroid
Phaeophyceae
Polysaccharides
Procyanidin
Proanthocyanidins
Polyunsaturated Fat
Paeoniflorin
Phytoestrogens
Polymethoxylated flavones
Rehmannia
Soy
Soy Protein
silica
Shilajit
Stilbenoid
Ursolic Acid
Vegetable Protein
Wakame
Xanthophyll
Other health conditions supported by Vitamin K mixed)
Bleeding (external)Bleeding (internal)
Blood Clots (prevention of)
Broken Bones
Bruises (healing)
Bruises (prevention)
Calcium Deficiency
Cardiovascular Disease
Cirrhosis of the Liver
Osteoporosis