Evidence supporting the use of: Agnuside
For the body system: Ovaries

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Table of Contents

Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Agnuside is an iridoid glycoside found in the fruits of Vitex agnus-castus (chaste tree), a plant traditionally used in Europe and the Mediterranean region for supporting female reproductive health. Historical records and traditional herbal medicine systems have long employed chaste tree extracts to manage menstrual irregularities, premenstrual syndrome (PMS), and symptoms associated with hormonal imbalances. The rationale for its use centers on its perceived effects on the hypothalamic-pituitary-gonadal axis, particularly in promoting the function of the ovaries and regulating the menstrual cycle.

While there is substantial traditional use supporting the application of chaste tree (and by extension, agnuside) for ovarian and menstrual health, scientific validation is less robust. Most modern research focuses on whole plant extracts rather than isolated agnuside, and clinical trials show some benefit for PMS and menstrual disorders, but causality is not solely attributed to agnuside. The evidence rating reflects the strong traditional use and some preliminary scientific support for the plant, but with limited direct evidence for agnuside itself.

In summary, agnuside’s use for ovarian support is primarily justified by traditional medicine, with moderate evidence from human studies on chaste tree extracts, but not on the isolated compound.

More about Agnuside
More about Ovaries

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