Evidence supporting the use of: DHEA
For the body system: Ovaries

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is a hormone naturally produced by the adrenal glands and is a precursor to both androgens and estrogens, including estrogen, which plays a key role in ovarian function. There is a growing body of scientific evidence supporting the use of DHEA supplementation, particularly in women with diminished ovarian reserve (DOR) or those undergoing assisted reproductive technologies (ART) like in vitro fertilization (IVF). Several studies and meta-analyses have indicated that DHEA supplementation in women with poor ovarian response may increase the number of retrieved oocytes, improve embryo quality, and potentially enhance pregnancy rates. The proposed mechanism is that DHEA may help modulate the ovarian environment, increasing levels of insulin-like growth factor-1 (IGF-1) and enhancing follicular development. However, while some randomized controlled trials and systematic reviews show promise, the quality of evidence is moderate, and not all studies report significant benefits. Professional guidelines, such as those from the American Society for Reproductive Medicine, note that more high-quality research is needed before DHEA can be routinely recommended for ovarian support. In summary, the use of DHEA to support ovarian function has scientific backing, especially in specific populations like women with low ovarian reserve, but the overall strength of evidence is moderate rather than definitive.

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