Evidence supporting the use of: Folic Acid
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folic acid, also known as vitamin B9, is scientifically validated as an important nutrient for female reproductive health, particularly in the context of preconception and early pregnancy. Its primary role in supporting the ovaries and the reproductive system is linked to its involvement in DNA synthesis, cell division, and methylation processes, which are crucial during periods of rapid cell growth such as oocyte (egg) maturation and embryonic development. Numerous clinical guidelines recommend folic acid supplementation for women of childbearing age to reduce the risk of neural tube defects in offspring, but evidence also extends to ovarian function. Research suggests that folic acid may improve oocyte quality, enhance follicular development, and support ovulation, especially in women undergoing fertility treatments. For example, several studies have observed that higher folate levels are associated with increased rates of conception and better outcomes in assisted reproductive technologies such as IVF. However, while the evidence for folic acid’s role in preventing neural tube defects is robust, direct evidence of its impact on overall ovarian health or long-term ovarian function is less conclusive, though promising. In summary, the use of folic acid to support the ovaries is backed by scientific evidence, particularly related to reproductive health and fertility, justifying its common inclusion in preconception and prenatal supplements.

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