Evidence supporting the use of: Gamma-linolenic acid
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma-linolenic acid (GLA) is an omega-6 fatty acid found in plant oils such as evening primrose, borage, and black currant seed oils. Its use to support the ovaries, particularly in the context of female reproductive health, has some scientific basis, albeit limited and not definitive. The primary focus of GLA research related to ovarian function is in conditions like premenstrual syndrome (PMS) and, less commonly, polycystic ovary syndrome (PCOS). Some randomized controlled trials and reviews suggest that GLA supplementation may help alleviate PMS symptoms, such as breast tenderness and cyclical mood changes, which are linked to ovarian hormone fluctuations. The proposed mechanism involves GLA's conversion to prostaglandin E1, which has anti-inflammatory properties and may help modulate hormonal balance. However, evidence for direct effects on ovarian health or function (such as follicle development or ovulation) is weak. Most studies are small, of short duration, and sometimes show conflicting results. There is not enough robust evidence to recommend GLA as a primary support for ovarian health, but it may have a modest effect on certain symptoms associated with ovarian hormone activity. Major medical organizations do not currently endorse GLA for ovarian support, and more large-scale, well-designed studies are needed.

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