Evidence supporting the use of: Osthole
For the body system: Ovaries

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Table of Contents

Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Osthole is a natural coumarin derivative found in several medicinal plants, most notably Cnidium monnieri, commonly used in Traditional Chinese Medicine (TCM). Historically, Cnidium monnieri and its active compound osthole have been used for a variety of gynecological concerns, including menstrual regulation and fertility support, which is why osthole is sometimes included in supplements or herbal preparations marketed for ovarian health. The traditional use is primarily based on empirical observations and long-standing practices rather than rigorous scientific validation.

There are a limited number of preclinical studies (in vitro and animal models) that suggest osthole may have some estrogen-like effects or may modulate hormones involved in female reproductive health. For instance, some studies have reported that osthole can promote follicular development or protect ovarian function in animal models. However, there is a lack of robust clinical trials in humans demonstrating clear benefits for ovarian health or function. Thus, while the use of osthole for supporting the ovaries has a traditional basis and some preliminary mechanistic support from laboratory research, it is not strongly validated by human clinical evidence.

In summary, osthole’s use for ovarian support is primarily rooted in traditional use, with modest preclinical evidence but no substantial clinical proof to date.

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