Evidence supporting the use of: Vitamin B9 (calcium methylfolate)
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin B9, particularly in the form of calcium methylfolate (the bioactive, methylated form of folate), is scientifically validated for its importance in supporting ovarian and overall female reproductive health. Folate is essential for DNA synthesis, repair, and methylation, which are crucial processes during oocyte maturation and early embryonic development. Deficiency in folate has been associated with impaired ovulation, reduced fertility, and increased risk of neural tube defects in offspring. Several studies and clinical guidelines recommend adequate folate intake—either through diet or supplementation—for women of reproductive age, especially those attempting to conceive. Calcium methylfolate, as a form of folate, is particularly beneficial for individuals with genetic variants (such as MTHFR mutations) that impair the conversion of folic acid to its active form. Supplementing with methylfolate ensures bioavailability needed for ovarian and reproductive functions. Research also indicates that folate supplementation may help reduce homocysteine levels, which, when elevated, can negatively impact fertility. While most evidence centers on folate’s role in fertility and early pregnancy rather than direct effects on ovarian tissue, the strong link between folate status and reproductive outcomes provides a scientific basis for using calcium methylfolate to support the ovarian system.

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