Evidence supporting the use of: Vitexicarpin
For the body system: Ovaries

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Table of Contents

Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Vitexicarpin, also known as casticin, is a flavonoid compound primarily found in the fruit of Vitex agnus-castus (chaste tree). The use of Vitex agnus-castus for supporting ovarian health and addressing menstrual issues has a long tradition in herbal medicine, especially in Europe. Historically, extracts of this plant have been used to help manage symptoms of premenstrual syndrome (PMS), menstrual irregularities, and other female reproductive concerns. The rationale in traditional medicine is that compounds like vitexicarpin may influence hormone regulation, particularly by modulating prolactin levels, though vitexicarpin itself is only one of many active constituents in the plant.

Scientific research on whole Vitex agnus-castus extracts demonstrates some benefits for premenstrual complaints and cycle regularity, but the specific role of vitexicarpin alone is less well studied. Most clinical trials and reviews focus on the complete extract rather than isolated compounds. Preclinical studies suggest that vitexicarpin may have some activity on hormone pathways, but robust, large-scale human data on this specific compound’s effect on ovarian function is lacking.

In summary, the use of vitexicarpin to support the ovaries is rooted primarily in traditional herbal practice, and while some supporting evidence exists for the parent plant, direct scientific validation for the isolated compound remains limited.

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