Evidence supporting the use of: Amylase (mixed amylase)
For the body system: Pancreas Head

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Amylase is a digestive enzyme primarily responsible for the breakdown of starches into simple sugars. It is produced by both the salivary glands and the pancreas, with the pancreatic amylase playing a major role in carbohydrate digestion in the small intestine. Supplemental mixed amylase is often used to support pancreatic function, particularly in cases where the pancreas is not producing sufficient digestive enzymes—a condition known as exocrine pancreatic insufficiency (EPI). Clinical guidelines and scientific studies support the use of enzyme replacement therapy, including amylase, in managing EPI associated with chronic pancreatitis, cystic fibrosis, or after pancreatic surgery. These supplements help improve nutrient absorption, reduce gastrointestinal symptoms (such as bloating, steatorrhea, and diarrhea), and support overall digestive health.

The efficacy of enzyme replacement therapy is well-established in the medical literature. For example, a 2016 review in Pancreatology emphasizes that pancreatic enzyme supplements containing amylase, lipase, and protease are the mainstay of treatment for EPI. While amylase alone is not used independently, its inclusion in mixed enzyme preparations is essential for comprehensive carbohydrate digestion. There is robust scientific backing for the use of enzyme mixtures including amylase to support the digestive function of the pancreas, especially in cases of pancreatic insufficiency. However, in healthy individuals without EPI or related conditions, the benefit of supplemental amylase is less clear and not generally recommended.

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