Enzyme blends, typically containing proteases, lipases, and amylases, are widely used to support pancreatic function due to the pancreas’s key role in secreting digestive enzymes. Scientific validation exists, especially regarding exogenous (supplemental) enzymes aiding digestion in individuals with pancreatic insufficiency, such as those with chronic pancreatitis, cystic fibrosis, or after pancreatic surgery. Multiple clinical studies have shown that pancreatic enzyme replacement therapy (PERT) improves nutrient absorption, reduces steatorrhea, and alleviates gastrointestinal symptoms in these populations. This is the basis for FDA-approved prescription products containing pancreatic enzymes derived from porcine sources.

While most robust evidence focuses on people with diagnosed insufficiency, some research also suggests that supplemental enzymes may aid general digestion, though data for use in healthy adults or for "pancreas support" outside of deficiency states is less conclusive. In summary, enzyme blends have strong scientific backing for supporting the pancreas in cases of impaired enzyme production, and moderate evidence exists for broader digestive support. However, claims that they “support the pancreas” in healthy individuals should be interpreted cautiously since the primary mechanism is to supplement, not stimulate, pancreatic function.