Evidence supporting the use of: Gymnemagenin
For the body system: Pancreas Head
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Gymnemagenin is a bioactive compound found in Gymnema sylvestre, a plant traditionally used in Ayurvedic medicine for managing diabetes and supporting general pancreatic function. The traditional use of Gymnema sylvestre (and by extension, Gymnemagenin) centers around its reputed ability to "destroy sugar," which has been interpreted as reducing sweet taste perception and helping control blood sugar levels. Most of the evidence supporting its use for pancreas support comes from its long-standing role in traditional medicine systems, rather than from rigorous clinical trials specifically evaluating Gymnemagenin's effect on the pancreas head or its function.
Some preclinical studies have isolated Gymnemagenin and investigated its effects on glucose metabolism and pancreatic beta cell health in animal models, suggesting a potential for stimulating insulin secretion or regenerating beta cells. However, direct, high-quality human studies on Gymnemagenin alone are lacking; most modern research has focused on whole plant extracts. Therefore, while there is a traditional and some preclinical scientific rationale for the use of Gymnemagenin-containing preparations to support the pancreas, robust clinical validation is limited. Its use is primarily justified by tradition with modest preclinical support, but not by high-level scientific evidence.
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berberine
bitter melon
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chromium
cinnamon
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turmeric
dandelion
fenugreek
gentian root
ginseng
gurmar
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moringa
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potato starch
protease
protein
starch
stevia
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mulberry
xylitol
zinc
β-nicotinamide mononucleotide (NMN)
jiaogulan
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enicostemma littorale
pterocarpus marsupium
swertia
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ganoderma
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fungal enzymes blend (proprietary)
nopal
AMP-activated protein kinase (AMPK)
enzymes blend (proprietary)
4-hydroxyisoleucine
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Bitter principals
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Other body systems supported by Gymnemagenin
Gastrointestinal TractPancreas Head
Pancreatic Tail
Small Intestines