Polygonatum kingianum, also known as King Solomon's Seal, is a traditional medicinal plant extensively used in Chinese medicine. Its use primarily stems from historical and ethnobotanical practices rather than robust scientific evidence. In Traditional Chinese Medicine (TCM), Polygonatum kingianum is classified as a tonic herb believed to nourish the yin, moisten dryness, and support the function of the spleen and pancreas, which in TCM theory are closely associated with digestive health and metabolic balance. Specifically, TCM texts often refer to the herb's ability to "strengthen the spleen and supplement qi," indirectly pointing to pancreatic support—especially as the pancreas is linked to the body's ability to process sugars and nutrients.

Scientific investigations into Polygonatum kingianum have mostly focused on its antioxidant, anti-inflammatory, and antidiabetic potential. Some preliminary in vitro and animal studies suggest that extracts of the plant may have hypoglycemic effects and could improve insulin sensitivity. However, direct high-quality clinical evidence linking Polygonatum kingianum to specific support or healing of the pancreas head or its functions in humans is lacking. The majority of available research does not distinguish between general antidiabetic activity and direct effects on the pancreas, and few, if any, clinical trials have been performed.

In summary, the use of Polygonatum kingianum for pancreatic support is rooted in tradition, with some weak scientific rationale but no strong clinical validation to date.