Evidence supporting the use of: Proteolytic enzyme (unspecified)
For the body system: Pancreas Head

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proteolytic enzymes, including pancreatin (a mixture of amylase, lipase, and protease), bromelain, and papain, have been studied for their role in supporting pancreatic function, particularly in cases of exocrine pancreatic insufficiency (EPI) or digestive disorders. The pancreas is responsible for producing digestive enzymes, and supplementation with proteolytic enzymes can help compensate for decreased endogenous enzyme production, improving nutrient absorption and reducing gastrointestinal symptoms such as steatorrhea, bloating, and malnutrition. Clinical trials and reviews have shown that enzyme replacement therapy is effective in managing pancreatic insufficiency, especially in conditions like chronic pancreatitis, cystic fibrosis, and after pancreatic surgery. However, most studies focus on defined enzyme preparations rather than "unspecified" proteolytic enzymes, and the efficacy depends on the formulation and dosing. There is less support for the use of proteolytic enzymes in healthy individuals, and the benefits for general "pancreas support" outside of diagnosed insufficiency are not well established in the scientific literature. In summary, scientific evidence supports the use of proteolytic enzymes for pancreatic insufficiency, but not broadly for pancreas "support" in healthy people.

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