Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Specialized pro-resolving mediators (SPMs), including resolvins, protectins, and maresins, are bioactive lipid compounds derived from omega-3 fatty acids. They have garnered scientific interest for their role in actively resolving inflammation. In the context of pancreatitis—a condition marked by acute or chronic inflammation of the pancreas—preclinical studies have demonstrated that SPMs may help limit tissue injury, modulate immune cell recruitment, and promote resolution of inflammation, distinguishing them from general anti-inflammatory agents that merely suppress inflammatory pathways.

Most of the evidence to date comes from animal models. For example, studies in mice and rats with experimentally induced pancreatitis have shown that administration of SPMs (notably resolvin D1) can attenuate the severity of pancreatic inflammation, reduce levels of pro-inflammatory cytokines, and improve histological outcomes. These findings suggest that SPMs may protect pancreatic tissue and support faster recovery. The proposed mechanisms include inhibition of neutrophil infiltration, promotion of macrophage-mediated clearance of cellular debris, and restoration of tissue homeostasis.

However, clinical evidence in humans is lacking as of June 2024. There are no large-scale clinical trials directly assessing the efficacy or safety of SPM supplementation in patients with pancreatitis. Thus, while the biological rationale is compelling and preclinical results are promising, the overall evidence is still preliminary, and recommendations for clinical use must be made with caution until human studies are available.

More about specialized pro-resolving mediators (SPMs)
More about Pancreatitis

Other ingredients used for Pancreatitis

Other health conditions supported by specialized pro-resolving mediators (SPMs)

Products containing specialized pro-resolving mediators (SPMs)

Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM