Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lion's mane mushroom (Hericium erinaceus) has gained attention in recent years for its potential neuroregenerative properties. The scientific interest primarily stems from its content of bioactive compounds such as hericenones and erinacines, which have been shown in preclinical studies to stimulate nerve growth factor (NGF) synthesis and promote neuronal growth and repair. In animal models, lion's mane extracts have demonstrated the ability to enhance recovery after nerve injury, reduce neuronal cell death, and improve motor function following damage to the nervous system. Some rodent studies have shown improved outcomes in models of peripheral nerve crush injuries and spinal cord injury, suggesting a possible role in supporting recovery from certain forms of paralysis.

However, clinical evidence in humans is very limited. Only a few small-scale studies and case reports exist, none of which directly address paralysis as a primary outcome. Most human research has focused on cognitive function or mild peripheral neuropathy, rather than substantial motor deficits or paralysis. While the mechanistic and animal data are promising, there is currently insufficient clinical evidence to support lion's mane as a treatment for paralysis in humans. More rigorous, controlled clinical trials are needed to establish efficacy and safety for this specific indication.

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