Evidence supporting the use of: American Pawpaw
For the health condition: Parasites (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

The use of American Pawpaw (Asimina triloba) to support or treat parasitic infections is grounded mainly in traditional medicine, particularly among some Native American groups and in Appalachian folk remedies. Historically, various parts of the pawpaw tree—including the bark, seeds, and leaves—have been used for their purported medicinal properties, including as remedies for lice and other parasites. Traditional uses often involved topical application rather than ingestion, especially considering the toxicity of certain pawpaw compounds. On a scientific level, limited studies have identified bioactive compounds in pawpaw, notably annonaceous acetogenins, which exhibit insecticidal and cytotoxic properties. Some laboratory research has shown these compounds to be effective against certain parasites and insects, including head lice. However, robust clinical studies in humans for internal parasitic infections are lacking, and the safety profile for such uses is not well established. Thus, while there is some preliminary biochemical rationale, the evidence remains weak and primarily anecdotal or based on traditional practices. In summary, American Pawpaw's use for treating parasites is supported primarily by tradition, with some in vitro scientific support, but lacks strong, direct clinical evidence for efficacy or safety in this context.

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