Evidence supporting the use of: Antimony potassium tartrate
For the health condition: Parasites (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Antimony potassium tartrate, also known as tartar emetic, has a well-documented history in the scientific literature as a treatment for parasitic infections, particularly schistosomiasis (formerly known as bilharzia). Its use dates back to the early 20th century, when it became a mainstay in the treatment of this parasitic disease caused by blood flukes of the genus Schistosoma. This compound acts as an antimonial drug, interfering with the parasite's metabolism and leading to its death. Numerous clinical studies and reports from the 1920s through the 1960s detailed its efficacy in reducing parasite loads and improving symptoms in infected individuals.

However, the use of antimony potassium tartrate was limited by its significant toxicity, including risks of cardiotoxicity, hepatotoxicity, and gastrointestinal distress. With the advent of safer and more effective antiparasitic drugs, such as praziquantel, the use of antimony potassium tartrate has largely been discontinued in modern medicine. Nonetheless, its role in the historical development of antiparasitic chemotherapy is well established, and its efficacy is supported by extensive scientific documentation from the pre-praziquantel era, warranting a relatively high evidence rating for its antiparasitic effects despite modern safety concerns.

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