Evidence supporting the use of: Chenopodium
For the health condition: Parasites (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Chenopodium, particularly Chenopodium ambrosioides (commonly known as epazote or wormseed), has a long history of traditional use as an anthelmintic—an agent used to expel parasitic worms (helminths) and other internal parasites. Historical records from indigenous peoples in Central and South America, as well as 19th- and early 20th-century Western herbal medicine texts, document its use for treating intestinal worm infestations such as roundworm (Ascaris lumbricoides) and hookworm. The seeds and oil (oil of chenopodium) were especially valued for this purpose. The anthelmintic properties are primarily attributed to the compound ascaridole, a monoterpene peroxide found in the essential oil. While there is some laboratory and clinical evidence from the early 20th century supporting its effectiveness against parasites, concerns about toxicity—particularly neurotoxicity and liver toxicity—have limited its modern medical use. Safer and more effective pharmaceutical anthelmintics have largely replaced it in conventional medicine. Nonetheless, traditional use persists in some cultures, and the historical documentation is robust. Modern research is limited, so the evidence rating reflects strong traditional use with some historical scientific observation, but a lack of rigorous, recent clinical trials.

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