Colombo, referring to the root of Jateorhiza palmata (also known as calumba or columbo root), has a longstanding history in traditional medicine, particularly in Africa and India. It has been traditionally used as a bitter tonic to stimulate appetite and aid digestion, and in some cultures, it has been employed to address intestinal parasites and related digestive disturbances. The rationale for its use against parasites is largely based on its general tonic and purgative properties, believed to help expel worms and improve gastrointestinal health. However, the traditional use is not focused on direct antiparasitic action, but rather on supporting the body's overall ability to recover from digestive illnesses, which sometimes included parasitic infestations.

Modern scientific evidence supporting the use of Colombo root specifically for the treatment of parasites is limited. There are a few early reports and herbal compendiums referencing its use for 'worms,' but no robust clinical trials or pharmacological studies confirm its efficacy as an antiparasitic agent. The root contains alkaloids and bitter principles such as columbin, which may contribute to its traditional applications, but these compounds have not been conclusively shown to possess significant antiparasitic properties. Therefore, while its use is justified by tradition, the strength of evidence is relatively low.