Evidence supporting the use of: Combretum quadrangulare
For the health condition: Parasites (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Combretum quadrangulare, a plant native to Southeast Asia, has a long history of use in traditional medicine, particularly in Thailand, Laos, Cambodia, and Vietnam, for treating parasitic infections. The roots and seeds of the plant have been employed as anthelmintic agents to expel intestinal worms, especially roundworms and threadworms. Historical texts and ethnobotanical surveys document its traditional use for these purposes, and it is included in several Southeast Asian herbal pharmacopeias for this indication.

Some preliminary scientific studies have explored the plant's antiparasitic potential. For example, extracts from Combretum quadrangulare have shown in vitro activity against certain parasitic worms, such as Ascaris lumbricoides, and in vivo efficacy in animal models. The anthelmintic effect is thought to be due to the presence of compounds like combretol and its glycosides. However, robust clinical trials in humans are lacking, and most evidence remains at the preclinical or anecdotal level.

In conclusion, the use of Combretum quadrangulare to support the treatment of general parasites is primarily justified by traditional practices, with some supporting preclinical research but insufficient high-quality clinical evidence to fully validate its efficacy and safety for this indication.

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