Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Holarrhena antidysenterica has a long history of use in traditional medicine systems, particularly Ayurveda, for treating intestinal parasites and related gastrointestinal disturbances. The seeds and bark of the plant, known as "Kutaja" or "Indrajao," are frequently cited in classical Ayurvedic texts as remedies for various types of intestinal worms (helminths), including roundworms and threadworms. The plant is commonly used in formulations intended to cleanse the digestive tract, reduce dysentery, and alleviate symptoms associated with parasitic infections, such as diarrhea and abdominal pain.

Scientific research on Holarrhena antidysenterica’s antiparasitic efficacy is limited but promising. Some in vitro and animal studies have demonstrated that extracts from the seeds and bark possess anthelmintic activity against certain types of parasitic worms. For example, ethanolic and aqueous extracts have shown significant effects in paralyzing and killing worms in laboratory settings. These properties are thought to be due to alkaloids such as conessine, which are present in the plant. However, rigorous clinical trials in humans are scarce, and most evidence remains preclinical or anecdotal.

In summary, Holarrhena antidysenterica’s use for treating parasites is well-rooted in traditional medicine and supported by moderate preclinical evidence, but robust human clinical data are lacking. Thus, while tradition justifies its use, more scientific validation is needed to confirm its efficacy and safety for this purpose.

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