Evidence supporting the use of: Java brucea
For the health condition: Parasites (general)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Java Brucea (Brucea javanica) has a long history of use in traditional medicine, particularly in Asia, for the treatment of various parasitic infections. In Traditional Chinese Medicine (TCM), Brucea javanica seeds are used to treat conditions such as malaria and intestinal parasites. The traditional basis stems from empirical use, and the herb is described as having properties that "clear heat" and "eliminate toxins," which are interpreted in TCM as being relevant to infectious and parasitic diseases.

There is some scientific interest in Brucea javanica's antiparasitic effects, particularly against malaria. Laboratory studies have demonstrated that extracts of Brucea javanica exhibit antiplasmodial activity in vitro, and some animal studies have shown efficacy against Plasmodium species (the parasite responsible for malaria). The active compounds, such as quassinoids (notably bruceine A and bruceantinol), are thought to disrupt parasite metabolism or replication. However, robust human clinical evidence remains limited, and most modern use for parasites is still based on traditional practices rather than large-scale, high-quality clinical trials.

In summary, while there is preliminary scientific support for the antiparasitic action of Java Brucea, especially for malaria, its primary justification for use comes from traditional medicine, with moderate supporting evidence from laboratory and animal studies.

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