Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Ajoene is a sulfur-containing compound derived from garlic (Allium sativum). Its use for treating or supporting the management of parasitic infections, particularly nematodes and worms, is primarily based on traditional medicine practices. Garlic has a long-standing reputation in various cultures as a remedy for intestinal worms and other parasites. Historical texts and ethnobotanical reports from Asia, Africa, and Europe describe the use of garlic and its preparations for deworming and treating parasitic infestations. While ajoene itself is a specific compound isolated from garlic, most traditional uses refer to whole garlic or garlic extracts, which naturally contain ajoene among other sulfur compounds. The proposed mechanism behind its anti-parasitic effect is related to the general antimicrobial and antiparasitic properties of garlic’s organosulfur compounds, including ajoene. Some in vitro studies suggest ajoene may disrupt parasite cell membranes or metabolism, but robust clinical data in humans are lacking. Overall, while there is a plausible biological basis and a history of use for garlic against worms, the direct evidence for ajoene specifically is limited and mainly supported by traditional practices, not modern clinical trials. Thus, the justification for its use in this context is predominantly traditional, with a moderate but not strong level of supporting evidence.

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