Evidence supporting the use of: American Pawpaw
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

The use of American Pawpaw (Asimina triloba) to support or treat parasitic infections, such as those caused by nematodes and worms, is primarily based on traditional and ethnobotanical practices rather than robust scientific validation. Historically, indigenous peoples and traditional herbal practitioners in North America have used parts of the pawpaw tree for a variety of medicinal purposes, including as an anthelmintic (a substance that expels or destroys intestinal worms). This traditional use is likely linked to the presence of annonaceous acetogenins, a group of bioactive compounds found in pawpaw, which have demonstrated antiparasitic and insecticidal activity in laboratory studies. However, while some in vitro and animal studies suggest that acetogenins from pawpaw possess antiparasitic properties, there are no well-controlled human clinical trials specifically assessing its efficacy or safety for treating nematode or worm infections. Most of the available evidence remains preclinical, and concerns about toxicity and side effects (especially neurotoxicity with high or prolonged exposure) have been raised. In summary, the use of American pawpaw for parasites is supported by traditional practices and some preliminary scientific findings, but lacks rigorous clinical evidence. It should not be considered a first-line or proven treatment for parasitic infections in humans. Consultation with a healthcare provider is recommended before using pawpaw for medicinal purposes.

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