Evidence supporting the use of: Antimony potassium tartrate
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Antimony potassium tartrate, also known as tartar emetic, has a well-documented history of use as an antiparasitic agent, particularly against certain nematode and protozoan infections. Its use dates back to the 19th and early 20th centuries, where it was employed to treat schistosomiasis (a parasitic disease caused by Schistosoma species) and other helminthic infections. The scientific basis for its use derives from clinical trials and reports demonstrating its efficacy in killing or inhibiting the growth of parasites, particularly schistosomes and, to a lesser extent, some nematodes. The mechanism of action is believed to involve interference with the parasite’s energy metabolism, leading to paralysis and death of the worms.

However, antimony potassium tartrate is associated with significant toxicity, including cardiac and hepatic side effects, which has led to its replacement by safer and more effective drugs such as praziquantel and mebendazole. Despite its historical and early scientific validation, current clinical guidelines do not recommend its use due to the risk profile. Still, the evidence supporting its antiparasitic activity is robust and well documented in medical literature, earning it a high evidence rating for historical efficacy, albeit not for current practice due to safety concerns.

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