Evidence supporting the use of: Calotropis gigantea
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Calotropis gigantea, commonly known as the "crown flower," has a long history of use in traditional medicine systems, particularly in Ayurveda and folk medicine in India and Southeast Asia. Traditionally, various parts of the plant—especially the latex, leaves, and roots—have been used to treat parasitic infections, including those caused by intestinal worms (helminths) and nematodes. The plant is often administered as a decoction, powder, or paste, and sometimes combined with other herbal ingredients to enhance its anthelmintic (anti-parasitic) effects.

Scientific validation for these uses is limited, but some in vitro and animal studies have reported that extracts from Calotropis gigantea exhibit anthelmintic activity. For example, studies in rats and earthworms have shown that both aqueous and alcoholic extracts can cause paralysis and death of worms, suggesting some degree of efficacy. The latex contains cardenolides and other bioactive compounds, which are believed to contribute to its anti-parasitic effects. However, these studies are mostly preliminary, and there are few rigorous clinical trials in humans. Toxicity is also a concern, as Calotropis gigantea contains compounds that can be harmful at higher doses.

Therefore, while the traditional use of Calotropis gigantea for treating parasitic infections is well documented, scientific evidence remains limited and largely preclinical. More research is needed to confirm its safety and effectiveness in humans.

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