Evidence supporting the use of: Chenopodium
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Chenopodium, particularly Chenopodium ambrosioides (commonly known as epazote or wormseed), has a long history of traditional use as an anthelmintic (anti-parasitic) agent, especially in Central and South America. Historically, the plant’s essential oil, known as oil of chenopodium, was employed to expel intestinal worms, such as roundworms and hookworms, from both humans and animals. The principal active compound, ascaridole, is believed to be responsible for its anti-parasitic effects. Traditional use was widespread before the advent of safer and more effective pharmaceutical anthelmintics.

Scientific validation for its efficacy exists primarily in older literature; some studies from the early 20th century documented its effectiveness against certain intestinal nematodes. However, concerns about toxicity—especially neurotoxicity, hepatotoxicity, and gastrointestinal irritation—have greatly limited its modern medical use. Contemporary research is limited, and safer synthetic anthelmintics have largely replaced chenopodium in clinical practice.

In summary, the use of chenopodium for treating parasitic worms is primarily justified by tradition, with some historical scientific support, but its use is now rare due to safety concerns and the availability of better alternatives.

More about Chenopodium
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